الفهرس | Only 14 pages are availabe for public view |
Abstract The present work resulted in the formation of functionally substituted 1,2,4 triazoloquinoline, quinoline, chromene, coumarineimine, quinazoline, pyrazoloquinazoline and benzotriazolotriazine derivatives of potential biological importance using 5,5dimethyl1,3cyclohexanedione (1), activated nitriles 2 and 3 as starting materials. It has been found that, N(3,3dimethyl5oxocyclohexylidene)benzohydrazide (5), prepared via condensing 5,5dimethylcyclohexane1,3dione (1) with benzoylhydrazine (4), reacted with the arylidenemalononitriles 2a,b,d in ethanol containing piperidine as catalyst to afford 1,5,6,7,8,9hexahydro8,8dimethyl6oxo 5aryl2phenyl[1,5a]quinoline4carbonitriles 8ac. Similarly, N (3,3dimethyl5oxocyclohexylidene) benzohydrazide (5) reacted with the arylidenenitriles 2g,h in refluxing ethanol and in presence of piperidine to yield also 1, 5, 6, 7, 8, 9hexahydro5 aryl8,8dimethyl6oxo2phenyl[1,2,4] triazolo [1,5a] quinoline4carboxamides (12a,b). Structure of the newly synthesized compounds were elucidated on the basis of their elemental analysis and spectral data as well as chemical methods. |