الفهرس 
Introduction and Aim of WorkOnly 14 pages are availabe for public view
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Abstract
The present study included 44 males and 13 females, homogenous regarding age, Tx duration, BP with exclusion of pediatric cases, preTx diabetics, uncontrolled hypertension, diabetic neuropathy, acute illness and chronic infection e.g. TB, HCV. They were categorized into: healthy donors (15 subjects); renal transplant recipients who suffered from PTDM (16 recipients) & renal transplant recipients who did not suffer from PTDM (26 recipients). The comparison was done through serum markers for apoptosis in all groups; DNA degradation products and p53, whereas tissue markers; bax, bcl2 and bclxL were used for comparison between the two groups of renal transplant recipients. Results of our study showed : No significant difference among all groups regarding serum p53 (p value= 0.077) where as DNA was significantly higher in the diabetic than the nondiabetic group (p value=0.017). About 66.6% of DNA positive cases were euglycemic but suffered from CAN. The remaining cases (33.4%) had high fasting blood sugar with or without CAN. A statistically significant effect of CAN on serum DNA & p53 was found in the studied groups (p value=0.032, 0.002 respectively). Bax was detected in renal tubular epithelial cells of 72.7% of the diabetic recipients & 76.5% of non diabetic group. The same cases were negative tissue staining for bcl2 and bclxL. Absence of a significant difference between both groups of recipients may be attributed to the proper control of blood sugar in most of cases at time of biopsy intake in RTxR with PTDM and the fact that apoptosis in these groups was affected by factors other than the glycemic state alone.