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Abstract Abnormal uterine bleeding in women above 40 years is one of the most distressing problem in females, the most common causes in premenopausal and postmenopausal women are, endometrial atrophy, estrogen replacement therapy, endometrial polyp, endometrial hyperplasia and endometrial carcinoma. Doppler velocimetry of the uterine artery carries a high sensitivity (100 %) in patients presenting with postmenopausal or perimenopausal bleeding. In brief, the presence of high resistance in uterine vessels may allow a more conservative approach in postmenopausal bleeding patients. Also, the use of colour Doppler to assess neovascularization and blood flow impedance in or around the endometrium could allow early detection of endometrial carcinoma. ” TVS and Doppler flow study represent non invasive diagnostic techniques to evaluate the patients with abnormal uterine bleeding. ” Real time TVS and Doppler are used complementary to each other and considered very suggestive investigations in the differentiation between benign and malignant endometrial lesions, and also in the staging of endometrial malignancy. ” We can save many patients from invasive techniques and risk of anesthesia by using TVS and Color Doppler Flow. ” On the other hand, indeterminate and equivocal cases of thickened endometrium, especially in postmenopausal women with variable and disco-ordinate ultrasound and Doppler findings should be investigated as potentially malignant and evaluated by biopsy. |