الفهرس 
PREMATURITYOnly 14 pages are availabe for public view
 |  | from | 113 |  |  |
| | | from | 113 | | |
Abstract
The aim of this prospective cohort study was to evaluate pre and post transfusion erythrocyte lead level in preterm neonates with birth weight of ≤ 1500 g (VLBW) receiving packed red blood cells (pRBCs) transfusions and correlate these levels to lead concentrations in the transfused pRBCs. And to evaluate maternal prenatal lead exposure and its effect on serum blood lead level.
Regarding maternal characteristics, 29 (64.4%) of our mothers were having history of lead exposure and 27 (60.0%) were delivered by cesarean section. While regarding fetal characteristics, 23 (51.1%) of included infants were females while 22 (48.9%) were males. The mean gestational age at time of delivery was 29.91 ± 2.03 weeks and their birth weights were ranging between 700 – 1500 gm with mean ± SD: 1228.44 ± 222.16 gm. The mean APGAR score at 5 min were 8.4 ± 0.72 (ranging between 6 – 9). Mean Hb level Pre-blood transfusion was 7.22 ± 1.5. While HCT percentage pre-blood transfusion was 28.86 ± 5.05.
Regarding prenatal maternal exposure to lead, our results showed that 64.4% of our participants were exposed to lead while 356% of them were not. When we compared between both those who exposed to lead and those not, our results showed that there was a statistically significant difference between groups regarding GA and birth weight.
Regarding pretransfusion hematological parameters, our results showed that the mean hemoglobin (Hb) concentration was 7.2 ± 1.5 g/dl and the mean hematocrit (HCT) percent was 28.9 ± 5.05%. While, regarding posttransfusion hematological parameters our results showed that that the mean hemoglobin (Hb) concentration was 11.2 ± 1.3 g/dl and the mean hematocrit (HCT) percent was 38.4 ± 4.8%.
Serum leads levels before transfusion were ranging between 0.3 – 23 μg/L with mean level 5.81 ± 4.74 μg/L and median value (IQR): 4.7 (0.71 - 1.8) μg/L. While the lead levels after transfusion were ranging 0.6 - 20 7 μg/L With mean level 79 ± 5.96 μg/L and median value (IQR): 7 (0.89 - 2.4) μg/L. the mean difference was 1.98 ± 4.37. The post- transfusion lead level was significantly higher than the pre-transfusion lead levels with p-value: 0.009. There was a significant correlation between the increase in posttransfusion lead level and lead levels in transfused pRBCs.