الفهرس | Only 14 pages are availabe for public view |
Abstract Uterine Leiomyomas, also called fibroids, are the most common benign gynecological tumor in premenopausal women . The economic impact of leiomyomas is profound. In Egypt, affecting from 9.8% to 17.8% in the age group of 40–49 years, and about 25 % of them underwent hysterectomy due to uterine fibroids (El-Hakim et al., 2022; Stewart et al., 2016). The pathogenesis of leiomyomas is still not well understood. However, Genetic predisposition has an obvious role in their pathogenesis. Analysis of single-nucleotide polymorphisms (SNPs) have been shown to be a possibility to identify gene associated diseases and could add to the knowledge of the development and progress of various neoplasms. Generally, polymorphisms are not directly linked to a certain disease and are therefore useful tools to study multi-factorial disorders such as uterine leiomyomata (Chen et al., 2011). Vascular endothelial growth factor (VEGF) plays a role in normal physiological functions such as bone formation, hematopoiesis, wound healing, and development. Angiogenesis is the main feature of benign and malignant tumours. VEGF is one of the most powerful endothelial cell mitogen and has a very critical role in normal physiological and tumor angiogenesis . It enhances tumour vessel permeability and endothelial cell proliferation, migration, differentiation, capillary formation and also has proinflammatory actions (Duffy et al., 2013). Several previous studies have reported the association between Interleukin-1b (IL-1b-511) and several diseases as atherosclerosis, rheumatoid arthritis, peritonitis and bowel disease (Church et al., 2008). |