الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Oral lichen planus is an ongoing (chronic) inflammatory condition that affects mucous membranes inside the mouth. Oral lichen planus may appear as white, lacy patches; red, swollen tissues; or open sores. These lesions may cause burning, pain or other discomfort. Oral lichen planus can’t be passed from one person to another. The disorder occurs when the immune system mounts an attack against cells of the oral mucous membranes for unknown reasons (autoimmune disorder). Symptoms can usually be managed, but people who have erosive oral lichen planus need regular monitoring because they may be at risk of developing mouth cancer in the affected areas.
Calprotectin is antimicrobial protein mainly secreted by neutrophilic granulocytes and monocytes. It can be identified in serum or other body fluids like urine, feces, cerebrospinal fluid, synovial fluid, or saliva. In the presence of calcium, calprotectin is capable of sequestering the transition metals manganese and zinc via chelation. Calprotectin is the only known antimicrobial manganese sequestration protein complex. It has been shown to play an important role in numerous inflammatory diseases and disorders
The aim of our work was to evaluate salivary calprotectin level in oral lichen planus patients . This study included 20 patients with oral lichen planus (patient group) and 20 apparently healthy sex and age matched persons who served as a control group.
The mean age of patients was 45 ±10 years, while in control it was 41 ±10 years. The patient group included 7males (35%) and 13 females (65%), while controls included 6 males (30%) and 14 females (70%). This study showed that the majority of the studied patients were females (70%). There were no statistically significant differences between both groups as regard age (P=0.301) ,sex(p=0.736) and smoking (P = 0.231).
The results of our study revealed that OLP group showed a statistically significant higher level of salivary calprotectin (391.5 pg/ml) as compared to control group (307.6 pg/ml) (P < 0.001).
The calprotectin level was higher in patients with dental caries (median = 448.7 pg/ml) than in those without (median = 372.4 pg/ml) but with borderline significance (P = 0.056). No significant differences were reported regarding candida infection (P = 0.757) and amalgam restoration (P = 0.765)
The studied patients with OLP demonstrated significantly higher dental caries (55% vs. 0%, P < 0.001) and candida (35% vs. 0%, P = 0.008). No significant differences were observed regarding HCV Ag (P = 1.0) and amalgam restoration (P = 0.231)
Patients with a progressive course demonstrated a significantly higher calprotectin level than those with a stationary course (median = 448.7 vs. 372.4 pg/ml, respectively, P = 0.046).
Statistically, ROC analysis was done for calprotectin to assess its role in OLP diagnosis. It revealed a significant AUC of 0.805 (P = 0.001), with a 95% confidence interval ranging from 0.669 – 0.941. The best cutoff was > 344.6, at which sensitivity and specificity were 80% and 70%, respectively. However, no significant correlation was found with the disease severity and clprotectin level.
Multivariate logistic regression analysis was done for salivary calprotectin level to predict OLP. It was a significant independent predictor of OLP (OR = 1.024, 95% CI = 1.008 – 1.039, P = 0.002), controlling for age, residence, and sex.