الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 88 |  |  |
| | | from | 88 | | |
Abstract
Background: Serum ferritin level act as an acute phase reactant can be elevated due to subacute genital tract infection leading to preterm premature rupture of membranes.Objective: To determine whether serum ferritin levels could be used as a predictive marker of premature rupture of membranes or notResearch Design: Cross sectional study.Setting: conducted in obstetrics and gynecology department, Minia universitySample: One hundred pregnant women with premature rupture of membrane during (30:37 weeks) gestational age who met the inclusion criteria was recruited. Tools: Blood samples are collected every 2 weeks according to the gastitional age for measuring cbc ,crp and serum ferritin level
Results: Out of the included subjects, 38 individuals tested positive for CRP, accounting for 38% of the total, while 62 individuals tested negative, representing 62% of the total. The average CRP level among the subjects is 16.54, with a standard deviation of 38.56 S. Ferritin in all the 3 assessments was significantly increased in CRP positive cases when compared with CRP negative cases. There was significant positive correlation between S. Ferritin and CRP. . With cutoff value 17.5 there was significant association between s. ferritin and CRP as sensitivity reached 98% and specificity was 84.3%.
Conclusion: ; the present study showed that elevated serum ferritin and CRP levels were predictive of spontaneous preterm premature rupture of membrane because it reflects an acute- phase reaction to subclinical infections. Serum ferritin was significantly elevated in preterm premature rupture of membranes when measured at three different assessments. The current study also revealed that here was significant positive correlation between S. Ferritin and CRP in preterm premature rupture of membrane. Recommendations: The current study was limited by small sample size, the lack of control group, being a single center study and relatively short follow up period. Further controlled studies with larger sample size and longer follow-up are needed to confirm our results and to identify risk factors of poor outcome.