الفهرس 
Systemic Lupus ErythematosusOnly 14 pages are availabe for public view
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Abstract
Background: As for the choroid and the kidney have a similar vascular design and systemic exposures. To date, few studies reported on relation between choroidal thickness in lupus nephritis patients and showed contradictable results between thinning or thickening compared to non-lupus nephritis only systemic lupus erythrematosus patients).
Objective: Comparison between the effect of systemic lupus erythematosus with and without lupus nephritis on choroidal thickness using spectral domain optical coherence tomography.
Patients and Methods: A total of 40 patients with systemic lupus erythrematosis were enrolled and divided into two equal groups; 20 systemic lupus erythrematosis diseased eyes group without lupus nephritis and 20 eyes of age- and sex- matched systemic lupus erythrematosis with lupus nephritis. Lupus activity was determined through Systemic Lupus Erythematosus Disease Activity 2000 (SLEDAI-2K). Patients with or without lupus nephritis (LN) were determined according to SlICC criteria 2012. Lupus nephritis was confirmed by renal biopsy.
Results: No differences were noted between study groups as regard age, sex and onset of SLE disease. However, there was negative correlation between age and onset of SLE disease with central subfoveal choroidal thickness among all the studied patients. Central subfoveal choroid was thicker among cases with lupus nephritis compared with another group at baseline and after 3 months.
Conclusion: Choroidal thickening in systemic lupus erythematosus appears to be thinner, particularly in the subset of patients with nephritis, suggesting more advanced systemic vascular disease. Choroidal responses to hemodynamic changes may also be altered in SLE.