الفهرس 
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Abstract
Deterioration of kidney function over months or even years is a hallmark of chronic renal disease. Kidney failure, cardiovascular disease, mineral bone issues, undernourishment, and an increased risk of death are among the major outcomes associated with chronic kidney disease (CKD) in both children and adults. In children with chronic kidney disease (CKD), there is a correlation between BNP and NT-pro BNP levels and echocardiographic markers of diastolic ventricular dysfunction and left ventricular hypertrophy (LVH). These common cardiovascular illnesses are a major contributor to the increased mortality risk in children with chronic kidney disease (CKD), particularly those who need dialysis for an extended period of time.
Finding out whether LVMMI is associated with CKD and if serum BNP may foretell left ventricular hypertrophy and dysfunction in CKD children was the driving force for this study.
This case-control cross-sectional study recruited sixty children with chronic renal illness from April 2020 to June 2022. Minia University Children’s Hospital’s Pediatric Department, Pediatric Outpatient Nephrology Clinic, and Pediatric Unit of Dialysis provided the minors. Thirty children were determined to be in good health. Prior to the parents of children participating in the research being able to offer written informed permission, the local ethics committee gave its approval.
Two groups were formed from them:
Six kids with severe renal disease made up group 1.
Within group 1a, we found 28 cases of chronic renal disease in children who were not dialyzed.
group 1b included 31 children with chronic renal disease who were dialyzed.
group 2 consisted of 30 children who seemed to be in good health, with the same ages and sexes as the children with CKD.
This study used echocardiography to evaluate the RVD, LVESD, and LVMI while the heart was in systole and diastole. In addition to a thorough medical history and physical examination, each child was tested for triglycerides, cholesterol, blood urea, creatine, albumin, serum BNP, kidney function (GFR) assessed using the Schwartz technique, and serum BNP.
The findings demonstrated that: BNP levels were higher in the CKD group than in the control group, with the dialysis-dependent CKD group exhibiting the highest values. There was a negative correlation between BNP levels and age, body mass index (BMI), glomerular filtration rate (GFR), vitamin D, hemoglobin and albumin levels, ejection fraction (EF), and the E/A ratio. A positive correlation was observed with BNP levels and left ventricular mass index (LVMI), serum urea and creatinine levels, parathormone hormonal level, and late diastolic mitral inflow velocity (A).
Our study demonstrates that B-type natriuretic peptide (BNP) levels are a highly selective and reliable predictor of LVH in children with chronic kidney disease (CKD).