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العنوان
Insights into the Antiviral and Immune Stimulatory Roles of Some Herbal Extracts Using NDV as a Model /
المؤلف
Ali, Ahmed Ibrahim Al-Sebaie.
هيئة الاعداد
باحث / أحمد ابراهيم السباعي
مناقش / حسني عبد الفضيل ابراهيم
مشرف / هشام احمد محمد خليفة
مناقش / محمد جبر السيد جبر
الموضوع
Antiviral. Stimulatory.
تاريخ النشر
2024.
عدد الصفحات
117 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
البيطري
تاريخ الإجازة
1/1/2024
مكان الإجازة
جامعة الزقازيق - كلية الطب البيطرى - الفارماكولوجي
الفهرس
Only 14 pages are availabe for public view

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from 143

Abstract

In this comprehensive study, the antiviral efficacy of ginseng and thyme vulgaris was meticulously evaluated in broiler chickens infected with the highly virulent Newcastle disease virus (NDV) genotype VII. A meticulously designed experiment encompassed eight distinct groups, each subjected to varied treatments, enabling a thorough investigation into the impact of ginseng and thyme vulgaris on critical parameters including mortality rates, body weight dynamics, weight gain patterns, haemagglutination inhibition (HI) titers, and viral shedding kinetics. The results were striking: untreated, non-vaccinated birds suffered a staggering 80% mortality rate, while those vaccinated exhibited an 80% survival rate, underscoring the protective efficacy of vaccination. However, the most compelling outcomes emerged from birds receiving concurrent thyme or ginseng oil supplementation alongside vaccination, showcasing remarkable 100% protection against mortality. Even more intriguing was the finding that simultaneous administration of both oils with vaccination conferred an impressive 90% protection rate. Moreover, birds treated with these oils exhibited reduced viral shedding, indicative of their potential to suppress viral replication. Enhanced humoral immune responses to NDV vaccines were evident post-oil administration, further corroborating their immunomodulatory effects. Noteworthy improvements in body weight and weight gain were observed across vaccinated birds receiving oil treatments, with similar benefits extending to non-vaccinated groups. These findings not only highlight the promising antiviral properties of ginseng and thyme vulgaris but also underscore their broader implications in poultry health management, warranting further exploration into their mechanisms of action and therapeutic potential.