الفهرس 
Risk factors for the development of psoriasis:
T- cell activationOnly 14 pages are availabe for public view
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Abstract
Nucleotide Binding Oligomerization Domain Containing 2 (NOD2) is a key player in the innate immune system. It primarily activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, which is crucial for immune responses. NOD2 is upregulated in psoriatic epidermis and can collaborate with toll-like receptors and regulate inflammatory and apoptotic signals involved in the disease pathogenesis.