الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Nephrotic syndrome is one of the most common glomerular diseases and is defined by edema, substantial proteinuria (>3.5 g/24 hours), hypoalbuminemia (<30 g/L) and hyperlipidemia. It is often associated with thromboembolism and an increased risk of infection. Endocrine abnormalities are common in NS patients.
As a primary endocrine organ, the thyroid plays an important role in kidney growth and function. Kidneys in return play a crucial role in metabolism and elimination of thyroid hormone. A variety of altered thyroid hormone levels and metabolisms such as hypothyroidism and subclinical hypothyroidism have been reported in nephrotic syndrome and chronic kidney disease patient.
However, the data related to different types of thyroid dysfunction in nephrotic syndrome, especially the relationship between thyroid function and pathological characteristics of nephrotic syndrome patients, are scarce. This study was to evaluate the thyroid hormone profile in patients with nephrotic syndrome, to identify clinical predictors of thyroid dysfunction in patients with nephrotic syndrome.
In this study a total of 150 patients with nephrotic syndrome were enrolled in the study. Out of them; 50 patients had normal thyroid function and 100 patients had thyroid dysfunction. The study was conducted at Nephrology Unit of Internal Medicine Department of Assiut University Hospital in the period between 2020 and 2022.
All participants were subjected to full history taking and clinical evaluation. In addition to; complete blood count, liver function test, kidney function tests, lipid profile, thyroid hormones and thyroid peroxidase antibodies were done. Renal histopathological types were recorded.