الفهرس 
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Abstract
Background: Oral squamous cell carcinoma is one of the most common cancers globally. Considering the drawbacks of the traditional treatment phytochemicals have been introduced to the research field with consideration of their minimal, or no side effects and good efficacy against cancer cells. The pomegranate peel and the blueberry extracts were very well-known phytochemicals in this context. Aim of the work: In the current study, the antioxidant content of the extracts of both pomegranate peel extract(PPE) and blueberry extract(BE), their cytotoxicity and cell migration (metastasis) effects on the HNO-97 tongue carcinoma cell line and comparing the results of these two different phytochemicals. Material and Methods: The antioxidant content was determined using ORAC assay for both extracts. Then, the cytotoxic levels of the extracts were assessed using SRB assay. The flow cytometric analysis apoptosis assay upon the previously determined Ic50 of both extracts was performed. Finally, the wound healing assay as a measure of the metastasis was performed for both extracts. All assays were performed on the HNO-97 cell line Results: Both extracts have shown high significant antioxidant capacity between the two extracts. Moreover, both extracts were observed conducting significant cytotoxicity among the cancer cells even at the lowest concentration. Furthermore, there was a dose-dependent declination in cytotoxicity levels in both extracts. Additionally, the Ic50 for PPE revealed six times more efficient cytotoxicity that of the BE. The flow cytometry apoptosis analysis, PPE has revealed very promising significant results in induction of (early and late) apoptosis as well as cancer cell necrosis.. Meanwhile, BE showed an insignificant effect on the cancer cells in means of apoptosis (early and late) as well as necrosis. Furthermore, the wound healing assay showed a significant inhibition of cell migration when treated with PE compared to insignificant effect when treated with BE. Conclusion: There were obviously three times higher antioxidants in the PPE than the BE. Which was reflected as six times more cytotoxic effect of PPE than BE, effective apoptotic induction as well as cancer cell migration inhibition of PPE compared to insignificant results of BE. This might give promising results for further investigations about using them as a treatment modality or as an adjunctive treatment to traditional chemotherapy and radiotherapy with oral cancer cases. Keywords: Phytochemicals, oral cancer, pomegranate, pomegranate peel, blueberry, cancer treatment, cell proliferation, metastasis, apoptosis.