Author: Ibrahim, Eman Ibrahim Elmoghazy./ Title: Evaluating The Effect of Obatoclax on Human Bladder Cancer Cell Line Derived from Biliharzia-Associated Bladder Cancer Patients /

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العنوان

Evaluating The Effect of Obatoclax on Human Bladder Cancer Cell Line Derived from Biliharzia-Associated Bladder Cancer Patients /

المؤلف

Ibrahim, Eman Ibrahim Elmoghazy.

هيئة الاعداد

باحث / Eman Ibrahim Elmoghazy Ibrahim

مشرف / Mohamed Kamel Hassan

مشرف / Ali Hussein AbuAlmaaty

مشرف / Mahmoud Mohamed Zakaria

مناقش / Sobhy El-Sayed. Hassab El-Nab

مناقش / Mohamed M.Omran

تاريخ النشر

2024.

عدد الصفحات

184 p. ;

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

Multidisciplinary تعددية التخصصات

تاريخ الإجازة

4/5/2024

مكان الإجازة

جامعة بورسعيد - كلية العلوم ببورسعيد - Zoology Department.

الفهرس

Only 14 pages are availabe for public view

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Abstract

Bladder cancer is the fourth most common kind of cancer. Mechanistic-based molecular-targeted treatments for cancer have advanced.
Obatoclax (GX15) is one of the inhibitors recommended as a tumor treatment. It’s exhibits constantbinding capabilities across all anti-apoptotic Bcl-2 members.
We have evaluated the anticancer effect of GX15 on squamous bladder cancer cell line (SCaBER). we demonstrated the cytotoxicity effect of GX15 through MTT assay. The growth inhibitory effect of GX15 was determined by Flowcytometry by affecting different cell cycle phases, Annexin V kit was used to evaluate apoptotic induction. Apoptosis-related genes, including BCL2 BAX and HRAS expression, were evaluated using QPCR.