الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
AD is among the most prevalent childhood illnesses, impacting about 6% to 20% of children globally. Also, it is frequently reported in the adult population.
Now, the intestinal microbiota is thought to be the biggest and most active part of the intestinal barrier and is essential for the immune system’s proper development as well as immunological tolerance. Dysbiosis, or changes in the microbiota’s composition and function, was linked to the onset and progression of several skin conditions, including AD.
Blood levels of Claudin-3 and IFABP may serve as a marker of gut permeability. Accordingly, we assessed the serum levels of claudin-3 and IFABP as markers of intestinal barrier integrity in patients with AD.
The mean age of onset was 3.46 ± 3.01 years, ranging from 1 month to 12 years.
In the AD patients group, normal delivery was reported in 18 patients (41.9%) while CS delivery was reported in 25 patients (58.1%). Among the control group, 16 patients (45.7) were delivered normally while 19 patients (54.3%) were delivered via CS. The majority of AD patients received breastfeeding (35 patients; 81.4%) while only 4 patients (9.3%) received bottle feeding and another 4 patients received both breast and bottle feeding. Whereas, in the control groups, breastfeeding, bottle feeding, and breast and bottle feeding were reported in 82.9%, 8.6%, and 8.6%, respectively. No statistically significant difference was found between the patients and control groups in terms of mode of delivery (p= 0.733) and feeding (p= 1.00).
The most frequently affected areas were the lower limbs (65.1%) and face and neck (58.1%) followed by the buttocks (46.5%), upper limbs (30.2%), trunk (9.3%), Back (7.0%), and finally whole body (2.3%)
Among the AD patients, a positive family history was reported in 21 patients (48.8%). According to the presence of other allergic diseases, 32 patients (74.4%) had allergic diseases in the form of food allergy (18 patients; 41.9%), bronchial asthma (12 patients; 27.9%), allergic rhinitis (6 patients; 14%), conjunctivitis (two patients; 4.7%), and sinusitis (one patient; 2.3%). The IgE among the AD patients ranged from 23.0 to 11100 IU/ml with a mean ± SD of 1235.93 ± 2433.15 IU/ml.
EASI score ranged from 4.80 to 52 with a mean ± SD of 15.44 ± 9.91. There were 6 patients (14.0%) with mild score, 29 patients (67.4%) with moderate score, 7 patients (16.3%) with severe score and only one patient (2.3%) with very severe score.
There was