الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
One of the most prevalent skin conditions in the world, acne vulgaris affects Millions of people and dramatically impairs their quality of life. Inflammatory mediators are released, skin becomes hyperkeratinized, sebum production increases, and Cutibacterium acnes colonizes the skin as part of the pathophysiology of acne. In addition to interfering with keratinocyte proliferation, C. acnes also has lipase, protease, and hyaluronidase activity that may damage the pilosebaceous unit and cause inflammation.
Additionally, C. acnes has the ability to activate keratinocyte-expressed toll-like receptors and protease-activated receptors, which in turn triggers the generation of interleukins and matrix metalloproteinases. Antibiotic-resistant C. acnes may be able to reduce the efficacy of acne treatment because of the strains of C. acnes that are cross-resistant to different antibiotics that evolve as a result of the extensive use of antibiotics for treatment of acne.
We aimed to assess the prevalence of cutibacterium acnes resistance to macrolides, doxycycline and clindamycin. This is a prospective observational cross sectional study. The study included 100 acne patients suffering from moderate to severe acne, recruited from dermatology outpatient clinic at Alexandria Main University Hospital.