الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
This study is aiming to evaluate the efficacy of the PDA/n-HA coat in improving the
mechanical and biological properties of the 3D PLA scaffold. The fused deposition modeling
technique was used to print blank PLA, PLA with embedded n-HA particles, and PLA
scaffold coated with PDA/n-HA by immersion. After matrices characterization for their
chemical composition and surface properties, testing the compressive strength was pursued
using a universal testing machine. The bioactivity of scaffolds was evaluated by monitoring
the formation of calcium phosphate crystals after simulated body fluid immersion by Xray
diffraction analysis. The compatibility of the scaffolds was evaluated by cell viability (MTT)
assay, Also the evaluation of cell adhesion and proliferation was assessed using Scanning
electron microscope and cone focal microscopy.
This study explored the efficacy of the PDA/n-HA coat in improving the mechanical
and biological properties of the 3D PLA scaffold. The bioinspired PDA/n-HA coat did not
affect the compressive strength of the PLA scaffold negatively, in contrast to PLA/n-HA
scaffold. Moreover, the naturally derived PDA coat incorporated with n-HA has shown
excellent biocompatibility with increased calcium phosphate deposition, almost without
cytotoxic effects. The enhancement of cellular activity and cellular adhesion shown by the
PDA/n-HA coated scaffold serves the purpose of having better bone formation and
regeneration for the in vivo translation of the PLA/PDA/n-HA platform.