الفهرس 
PrediabetesOnly 14 pages are availabe for public view
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Abstract
The relationship between cardiovascular diseases and
glucose metabolism has drawn a lot of attention for
decades. The central part of this attention was paid towards
the relationship between those diseases and Diabetes
Mellitus (DM) which is by far the most important systemic
metabolic disease we have ever known.
Numerous studies that prediabetes, a minimally
aberrant glycometabolism, has an independent relationship
with cardiovascular disease (CVD) and that it reflects an
escalation in the severity and complexity of CAD.
Aim of the work : The aim of our study was to assess the
correlation between both glycosylated hemoglobin
(HbA1c), fasting blood glucose (FBG) and the severity of
coronary artery disease in prediabetic patients undergoing
elective coronary angiography .
Methods : The study was conducted on 92 prediabetic
patients who underwent elective PCI in cardiology department in National Institute of Diabetes and Endocrinology and Cardiology Department of Menoufia University Hospitals After informed written consent was obtained, All
patients were subjected to the following:
Full history taking including: age, other
cardiovascular risk factors (smoking, hypertension,
dyslipidemia & family history of coronary artery disease).
Full clinical examination including :
- General and local cardiac examination.
- Vital signs including Blood pressure and HR.
- Routine laboratory investigations including :
- Complete blood count (CBC) - Fasting blood glucose
and HbA1c - Serum creatinine .
Coronary angiography: All individuals had coronary
angiography per standard protocols using the Judkins
technique. Standard views for Left and Right coronary
arteries. CAD severity was assessed using SYNTAX score
according to diagnostic algorithm.
Results: The mean haemoglobin was 13.0 ± 1.7, the mean
FBS is 117.8 ± 6.1, while the mean HbA1c was 6.1 ± 0.2.
The median of the SYNTAX score among the studied
patients was 6.5 (0 - 19). Low SYNTAX score was reported among 80.4% of the patients, intermediate score was 9.8%, while high score was reported 9.8% of the studied patients. There is a significant positive correlation
between number of vessel diseased and HbA1c, Also, there
is a significant positive correlation between HB%, FBS,
HbA1c and Syntax score. The median of the score was
significantly higher among males, smokers, hypertensive
patients, and those with positive family history for CAD.
No significant relationship was observed between the score
and age. Linear regression for predictive factors of
SYNTAX showed the number of VD was considered an independent predictor of severity of CAD. While sex, smoking, hypertension, HB%, FBS, and HbA1c werecofactors.