الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The condition known as chronic obstructive pulmonary disease (COPD) is very widespread and has several detrimental effects on morbidity and mortality. PFTs, or pulmonary function tests, can be used to assess the severity of COPD. In individuals with COPD, a FEV1/FVC ratio of less than 70% showed respiratory impairment. PFTs, however, have a few drawbacks, such as the challenge some patients have doing these tests due to their frailty, poor clinical health, or other conditions that impact test outcomes.
The study’s objective was to assess the accuracy of lung volume measures using computed tomographic (CT) images with thin section multidetector rows vs conventional pulmonary function tests. This prospective study involved 50 patients with a likely clinical diagnosis of COPD who were seen at the university hospital’s radiology and chest departments between September 2022 and May 2023.
Patients underwent a contrast-free CT chest scan to assess the severity, and software that automatically separated each lung lobe and calculated its capacity was used to create 3D models. A week before or following MDCT scanning, pulmonary function tests were administered to the patients in order to evaluate them.
Regarding the clinical aspect, many of the patients complained of symptoms including coughing 45 (90%), dyspnea 35 (70%), and chest discomfort 44 (88%). The majority of patients (44, or 88%) had a positive smoking history. Regarding the GOLD categorization, there were 10 GOLD 1 instances (20%), 16 GOLD 2 cases (32%), 18 GOLD 3 cases (36%), and 6 GOLD 4 cases (12%).
Emphysema grade differences across GOLD groups were statistically different (P 0.001). When compared to the GOLD 1-2 group, the LAV-950 HU (%) value of all lung parameters was higher in the GOLD 3-4 group.
The results of the current investigation demonstrate the existence of a strong correlation between all quantitative assessment parameters with -950 HU (%LAA) and the lung function tests (FEV1 and FEV1/FVC ratio). The FEV1/FVC ratio and all lung density measurements showed a highly significant negative connection
(p < 0.001 and r ≥ 0.5), as did the FEV1 and all lung density parameters.
Conclusion :
Emphysema quantitative CT measurements are a reliable, quick, and simple non-invasive assessment for assessing the severity of emphysema since they have a significant association with the parameters of pulmonary function tests.
Recommendation :
We advised regular chest CT studies for COPD patients to include CT quantification of emphysema.