الفهرس 
WEANING from MECHANICAL VENTILATION IN NEONATESOnly 14 pages are availabe for public view
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Abstract
Background: Mechanical ventilation is a lifesaving treatment used in critical neonatal patients. It is indicated when the patient’s spontaneous ventilation is insufficient to sustain life. Mechanical ventilation expedites and facilitates gas exchange, oxygenation, and CO2 removal. Despite advances in non-invasive ventilatory support methods, intubation and mechanical ventilation are still common treatments in NICUs.
Objective: To evaluate whether or not serum malondialdehyde (MDA), as a marker for oxidative stress, could be used as a mean to predict the neonatal weaning failure from mechanical ventilation.
Methods: This is a prospective cohort study will be included 31 Full and preterm neonates on invasive mechanical ventilation ≥72 hours was conducted in Neonatal Intensive Care Unit Ain Shams University, children Hospital, after approval of the Research Ethics Committee Faculty of Medicine Ain Shams University from March 2023 to September 2023.
Results: Our study revealed highly significant increase in serum level of MDA in weaning failure patient before extubation, after half and 72 hours of extubation, also it shows decrease in serum level in weaning success patients.
Conclusion: There is a high correlation between high level of serum MDA and weaning failure from mechanical ventilation.