الفهرس 
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Abstract
Both celiac disease and Type 1 Diabetes Mellitus have an atherosclerotic impact.
By assessing the C5protein level and Carotid Intima Media thickness in children with Type 1 Diabetes and celiac disease, the goal of this research was to identify early atherosclerosis.
In this research, 60 kids with Type 1 Diabetes Mellitus were enrolled. group (A) had 30 children who just had diabetes mellitus, while group (B) contained 30 children who also had celiac disease. 30 youngsters who seemed to be in good health were also included as a control group. The children had DM, and their ages and sexes were matched.
The studied groups were subjected to the following
1- Complete history-taking
2- Comprehensive clinical evaluation
3- Laboratory tests (random blood glucose, glycosylated hemoglobin, lipid profile of the serum, complement C5 protein)
4- Radiological tests
Doppler ultrasonography of the carotid arteries
The main results of the study revealed that:
In comparison to controls, diabetic children with and without celiac disease had substantially higher TG, TC, and LDL readings and lower HDL values.
Children with diabetes, both those with and those without celiac disease, showed substantially greater levels of C5 protein and carotid intima media thickness than did controls.
C5 protein blood levels are favorably linked with carotid intimal thickness in diabetic children with and without celiac disease.
Both Carotid intimal thickness and C5 protein were favorably connected with HbA1c, TC, TG, LDL, and the length of diabetes, according to the two study groups, whereas both were negatively correlated with HDL.
Conclusion
• Children with Type 1 Diabetes, whether they also have celiac disease or not, have higher levels of C5 protein and thicker carotid intima media, which are strong indicators of early atherosclerosis.
• Children with Type 1 Diabetes, both with and without celiac disease, may benefit from early atherosclerosis identification by measuring C5 protein and carotid intima media thickness.
Recommendations
from the results and conclusion of this study, we recommend that:
• The utilization of carotid intima media thickness and C5 protein as markers of early atherosclerosis in kids with type 1 diabetes and celiac illness.
• Regular evaluation of the thickness of the carotid intima media and the C5 protein levels. in kids with type 1 diabetes who also have celiac disease and those who don’t.
• Additional research with a bigger sample size and a wider geographic scope is required to confirm our findings and assess the use of C5 protein and CIMT in the management of type 1 DM patients with and without celiac disease.
• All kids with type 1 DM should get treatment to reduce the negative effects of atherosclerosis.