الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Multiple sclerosis (MS) is a common demyelinating and autoimmune disease of the central nervous system (CNS) with presumed autoimmune and multifactorial etiologies .
MS is the most common cause of non-traumatic neurological disability in young adults.
The aim of this work was to study the presence of psychiatric comorbidities in MS patients , mainly depression and anxiety , the risk factors for developing them and their effect on quality of life .
The study included 60 patients with MS. They were recruited from outpatient neurology clinics of Sohag University Hospitals and Sohag general hospital in an observational study .
Data of our study indicate increased prevalence of depression and anxiety in MS pateints , this was approved by doing a questionarre , HADS score, on all patients included in our study
Depression was found to be more prominent in males more than females , and in young age than older .Unemployment was also risk for developing depression . Low or intermediate education and unmarried was related to be a factor for developing depression . Long duration of illness and increase number of attacks were also risks .High EDSS and and low physical and mental assessment by MSQOL -54 quistionarre was also associated with developing of depression.
Anxiety was found to be more prominent in patients with low education and unmarrid and low physical and mental assessment by MSQOL -54 quistionarre .
Further research is needed to identify sources of heterogeneity. Issues to consider are the definition of depression and anxiety, patient recruitment, and patient characteristics.
Limitations
-Small sample size in our study.