الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Nephrotic syndrome (NS) is the most common glomerular disease
seen in the pediatric age group. It is the second most common kidney
disease seen in pediatric nephrology clinic, the most common being
congenital malformations of the kidney and the urinary tract. It is
characterized by massive proteinuria, hypoalbuminemia, peripheral edema
and hyperlipidemia.
Nephrotic syndrome in children is generally classified into steroid
sensitive nephrotic syndrome (SSNS) and steroid resistant nephrotic
syndrome (SRNS) based on the initial response to corticosteroid therapy
at presentation. This classification resulted from the International Study
of Kidney Disease in Children (ISKDC) studies in the 1970s,which
showed that irrespective of morphological changes on kidney biopsy, the
most important prognostic factor in NS is the response to corticosteroid
and other immunosuppress.
IL6-G/C rs1800795 is a SNP in the promoter of the
interleukin- 6 IL6 gene, affecting the levels made of this important
cytokine . It was first described in 1998, when it was shown
thatthe rs1800795(C) allele produces less IL6 than the (G) alleleits role
has been found in mesangial proliferative glomerulonephritis and endstage renal disease.
The work aimed to find the relation between cytokine genes promoter
polymorphisms (IL6G174C) and Nephrotic syndrome inchildren
The present study conducted in nephrology and genetics units,
pediatric department, Menoufia University Hospital on 90 children age
range from 2 -18 years, period of the study from September 2020 to April
2022
Inclusion criteria:
from 2-18 years
Duration of disease > 2 months
Both sexes
Idiopathic nephrotic syndrome both (SSNS & SRNS)
Exclusion criteria:
Congenital or Secondary Nephrotic syndrome
Syndromes and other auto immune disease.