الفهرس 
The influence of bisphenol (A) levels in men onOnly 14 pages are availabe for public view
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Abstract
Background: Recently much more observations indicates that bisphenol (A) which widely used as plastic monomer, is a reproductive toxicant of public health importance
Aim of the work: Evaluation the impact of urinary bisphenol (A) levels on semen parameters, sperm DNA damage of infertile males, embryo development and pregnancy rate during Intracytoplasmic Sperm Injection cases.
Methods: This study was planned as a prospective cohort study conducted at Banon IVF center, Asyut, Egypt between February 2019 and January 2020 in collaboration with Genetic Engineering and Biotechnology Research Institute, University of Sadat City. A case-control hospital-based study design was used, with the recruitment of 54 infertile couples presented to the Banon IVF center, to undergo ICSI and consented to join the study. Another 10 men, who were age, residence, socioeconomic class and abstinence period- matched to the study group, with normal semen profiles and who had fathered at least one child before, served as controls.
Results: The results indicated that exposure to bisphenol (A) resulted in a significant decline in sperm motility and vitality, however there was no association between bisphenol (A) and pregnancy outcome or live birth after ICSI. Higher sperm concentration and progressive motility and lower women BMI were significantly associated with pregnancy outcome after ICSI. There is statistically significant decline in sperm progressive motility and total motility percentages when bisphenol (A) concentrations were added till reach the peak of decline at concentration of 40mg/l. Additionally, there was statistically significant decline in vitality percentage when bisphenol (A) was added.
Conclusion: The results indicate that exposure to bisphenol (A) resulted in a significant decline in sperm motility and vitality, however there was no association between bisphenol (A) and pregnancy outcome or live birth after ICSI.
Key words: Bisphenol (A); Intracytoplasmic Sperm Injection; HPLC, Comet assay.
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