الفهرس 
Mechanisms of TNF mediated alteratuin in melanocyte function in vitiligoOnly 14 pages are availabe for public view
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Abstract
Background: Vitiligo is an acquired chronic de-pigmenting disorder characterized by white macules or patches corresponding histologically to a substantial loss of functioning epidermal pigment cells. MicroRNAs regulate posttranscriptional silencing of target genes. A single miRNA can target hundreds of mRNAs and influence the expression of many genes often involved in a functional interacting pathway. MiR-720 expression has been found to vary in the serum levels of women carrying fetuses with and without neural tube defects. The miR-19 microRNA precursor is a small non-coding RNA molecule that regulates gene expression.
Aimofthework: To detect the levels of micro RNA 720,19b in serum and tissue sample of Vitiligo patients compared with healthy control.
Patient and method: The study included 20 vitiligo patients and 20 healthy control. Micro RNA was extracted from serum and tissue biopsy of patients and control. using micro RNA extraction kit followed by reverse transcription of the micro RNA Then by using real time PCR and specific primers, we detected the concentration of both microRNAs 720 and 19bin both serum and tissue samples
Results: There was highly statistically significant increase in serum and tissue of miRNA720 and 19b in patients group. There was highly statistically significant positive correlation found between fold change of serum and tissue miRNA720 and serum 19b with extent and VASI score,
Conclusion: This study suggests that an increase in serum and tissue level of both miRna720 and19b may play an important role in the aetiopathogensis of vitiligo and its extent.
Keywords: Vitiligo, micro RNA 720, miR-19