الفهرس 
Chapter 1: Heart Failure with Preserved Ejection Fraction (HFPEF)Only 14 pages are availabe for public view
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Abstract
Background: This research aimed to evaluate the role of coronary microvascular dysfunction in alteration of left ventricular (LV) myocardial deformation.
Methods: This observational study involved 60 patients with LV ejection fraction (LVEF) >50% and coronary microvascular dysfunction (diagnosed by coronary angiography). TIMI frame count (TFC) was calculated for each patient. They were classified into 2 groups: 30 patients with heart failure and preserved ejection fraction (HFpEF) (cases group) and 20 patients without HF (control group). Speckle tracking echocardiography was used to evaluate LV deformation.
Results: The mean age of the studied patients was 58.8 ± 8 years. The frequency of diabetes mellitus, hypertension, & dyslipidemia were significantly higher in cases than controls. Cases had significant higher BMI (30 ± 4.48 vs. 27.3 ± 3.94 kg/m2, p=0.029). The total TFC in cases was 97.1 ± 22.9 and in controls was 79 ± 18.5, and this difference was statistically significant (p=0.005). Significantly decreased LV global strain was observed in HFpEF cases than in controls (−17.6 ± 2.14 % versus −19.5 ± 1.98%, p < 0.001). In cases with a higher TFC, the LV global strain decrease was more pronounced. There was a significant correlation between the LV global strain and total TFC (r=-0.470 and p=0.009).
Conclusion:
Patients with HFpEF exhibited higher total TFC reflecting more affected coronary microvasculature. Those patients had reduced LV global strain.
Coronary microvascular dysfunction probably leads to alteration of myocardial performance.