الفهرس 
Electrochemical techniquesOnly 14 pages are availabe for public view
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Abstract
Summary
Electrochemistry is a branch of chemistry involved with studying the oxidation and reduction reactions of compounds on electrode surfaces. It covers various applications such as electrosynthesis of metal nanostructures, nanopolymers and electroanalysis of active compounds of drugs. In this thesis, the electroanalysis of thioctic acid (TA) has been carried out using novel sensors. In general, the system of the electrochemical-based sensor is composed of a carbon paste electrode (CPE) modified with poly (1,5-diaminonaphthalene (DAN)) and copper-cobalt nanostructures. First, a carbon paste electrode was prepared by mixing graphite powder with paraffin oil in a mortar until a homogeneous paste was obtained. Then, poly (1,5- diaminonaphthalene) was formed on the CPE by successive cyclic voltammetry (CV) in an aqueous solution of 1.5- diaminonaphthalene dissolved in perchloric acid (HClO4). Then copper-cobalt nanostructures were deposited on poly(1,5-DAN)/CPE by electrodeposition of cobalt chloride, copper chloride and sodium sulfate solution. The modified surface was characterized by electrochemical impedance spectroscopy (EIS), scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDX). In addition, we optimized the effects of multiple cycles of deposition of Cu-Co nanostructures, and electro-polymerization of monomer 1,5-DAN, scan rate, and pH. The sensor showed good identification capabilities for TA. The linear responses obtained ranged from 0.6 μM to 150 μM with a detection limit of 0.48 μM for the modified CPE. The adsorption process controlled the oxidation of TA. We used the proposed sensor and method to determine TA in Thionerv tablets from Utopia Pharma company