الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The most common cause of leading permanent blindness worldwide is glaucoma. Ophthalmologists are paying more and more attention to how glaucoma affects the retinal vasculature, so we looked for better tools for early diagnosis and monitoring.
There is a growing evidence suggesting that glaucoma pathogenesis is related to vascular affection. Optical coherence tomography angiography (OCTA) is one of the latest noninvasive imaging techniques for studying the vasculature of the retina, optic nerve, and peripapillary region. It has been shown that glaucoma is related to the reduction in ocular blood flow but before the advent of OCTA, this has been a difficult area to study.
In our study we used OCTA vessel density to document, quantify and compare microvasculature changes in macula and peripapillary region between 22 healthy eyes versus 22 eyes with primary open angle glaucoma by SS-OCT-A. All subjects were undergone full history taking, complete ophthalmological examination and investigations.
The results of our study showed a statistically significant decrease in VD in the peripapillary region (P<0.001) and both, superficial (P<0.001) and deep (P=0.001) macular regions in POAG subjects. In all those areas, the VD decrease was more evident with increasing severity of glaucoma and more prominent structural changes. This illustrated that a functional damage (VD) was associated with more pronounced structural damage (RNFLT, GCC).
The peripapillary and superficial macular VD generally outperformed the deep macular VD, as a diagnostic test differentiating between POAG and healthy eyes. All of this signify that the potential role of OCTA in both diagnosing POAG and get OCTA a foothold in more future studies evaluating its usefulness.