الفهرس 
Natural originOnly 14 pages are availabe for public view
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Abstract
Chalcones, considered to be the precursor of flavonoids and
isoflavonoids are abundant in edible plants. They consist of open-chain
flavonoids in which the two aromatic rings are joined by a three-carbon α,
β-unsaturated carbonyl system. Studies revealed that compounds with a
chalcone-based structure have anti-inflammatory, antibacterial,
antifungal, and antitumor activities. Acetophenone reacted with
Thiophenaldehyde in the presence of Sodium metal and Ethanol to
produce chalcone 1 in 75% yield (Scheme 1).
( Scheme 1).
Chalcone 1 react with Hydrogen proxide in basic mediam using
methanol as solvent for 2 hours with stirring gave 2 in 70 % yield
(Scheme 2).
1 2
( Scheme 2).
Chalcone 2 reacted with Hydrazinehydrate in Ethanol to afford 3 in yield
73% (Scheme 3).
(Scheme 3).
React 2 with phenylhydrazine by refluxing in Ethanol as solvent
afforded 4 in 65% yield (Scheme 4).
(Scheme 4).
Treatment of 2 with Hydroxylaminehydrochloride in presence of
Triethylamine in
Ethanol as solvent afforded 5 in 58% yield (Scheme 5).
(Scheme 5).
Treatment of 2 with Urea in presence of Ethanol as a solvent by
reflux afforded 6 in 59% yield (Scheme 6).
(Scheme 6).
Treatment of 2 with Thiourea in Ethanol by reflux afforded 7 in 55%
yield (Scheme 7).
(Scheme 7).
Treatment of 3 with Acrylonitril in presence Triethylamine in
ethanol by reflux afforded 8 in 66% yield (Scheme 8).
(Scheme 8).
Treatment of 6 with Acrylonitril in presence Triethylamine in
ethanol by reflux afforded 9 in 64% yield (Scheme 9).
(Scheme 9).
Treatment of 7 with Acrylonitrile in presenceTtriethylamine in ethanol by
reflux afforded 10 in 61% yield (Scheme 10).
(Scheme 10).
Treatment of 8 with Sodiumazide and Ammoniumchloride in presence
of DMF afforded 11 in 65% yield (Scheme 11).
Condensation of 9 with Sodiumazide and Ammoniumchloride in
presence DMF afforded 12 in 68% yield (Scheme 12).
(Scheme 12)
Treatment of 10 with Sodiumazide and Ammoniumchloride in presence
DMF to afford 13 in 61% yield (Scheme 13).
(Scheme 13).
Treatment of 11 with Ethylchloroacetate +anhydrous potassiumhydroxid
in presence acetone as solvent to affored 14 in 54% yield (scheme 14)
(Scheme 14).
Treatment of 12 with Ethylchloroacetate +anhydrous potassium hydroxid
in presence acetone as solvent to affored 15 in 56 % yield (scheme 15)
Treatment of 13 with Ethy chloroacetate +anhydrous potassium hydroxid
in presence acetone as solvent to affored 16 in 62% yield (scheme 16)
(Scheme 16).
Treatment of 14 with Hydrazinehydrate in Ethanol to offered 17 in 58%
yield (scheme 17)
(Scheme 17).
Treatment of 15 with Hydrazinehydrate in Ethanol to offered 18 in 59%
yield (scheme 18)
(Scheme 18).
Treatment of 16 with Hydrazinehydrate in Ethanol to offered 19 in 53%
yield (scheme 19).
(Scheme 19).