الفهرس 
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Abstract
Acute liver failure (ALF) is a life-threatening clinical syndrome manifested by jaundice, ascites, hepatic encephalopathy, and a bleeding tendency in a patient without previously known liver disease. To date, the Management of severe ALF is through liver transplantation which carries several disadvantages.
Acetaminophen (APAP) hepatotoxicity considered most important cause of death and liver failure worldwide and dose-dependent (6 to 10 g is required for ALF to occur).
Carbon tetrachloride CCl4 is highly toxic liquid compound belonging to the family of organic halogen, high doses (>1 mL/kg) do cause re producible acute liver injury that resembles drug toxicity. It is the most common model of induced acute liver failure.
Stem cells are unspecialized immature progenitor cells that can self-renewal and differentiate into multiple cell lines. Platelet-rich plasma (PRP) is an autologous plasma solution that expresses various growth factors.
The present study aimed to evaluate the biochemical, histological, and immunohistochemical changes induced by stem cells alone and in combination with PRP on rat liver treated with carbon tetrachloride (CCL4) and Acetaminophen (APAP).
The current study was carried out on seventy male albino rats assigned to five groups as follows:
I. group I (control group): 10 rats were injected intraperitoneally with sterile saline.
II. group II (carbon tetrachloride treated group): 10 rats received a single intraperitoneal injection of 50% CCl4 in olive oil at 2.5 ml/kg (1:1).
III. group III (Acetaminophen (APAP)-treated group): 10 rats received a single intraperitoneal injection of APAP 1gm/kg dissolved in sterile saline.
IV. group IV (stem cell group): 20 rats received a single intraperitoneal injection of APAP 1gm/kg dissolved in sterile saline and then were injected with stem cells (3 x106 cells/ml: 1ml/kg) 24 h after APAP injection.