الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
Acute Coronary Syndrome is one of the leading causes of death worldwide with high prevalence, morbidity and mortality. However, the age of ACS onset has decreased because of environmental risk factors and genetic polymorphisms. ACS is influenced by genetic, environmental factors, family history of CAD, obesity, inflammation, hypertension, dyslipidemia, diabetes and smoking; all are factors that constitute a major risk factor for ACS.
It was found that serum VEGF-A levels are positively associated with increased microvessel density in the infarcted area suggesting VEGF-A role in myocardial remodeling and angiogenesis as when cells are deprived of oxygen, they increase their production of VEGF-A which mediates the growth of new blood vessels from pre-existing vessels (angiogenesis) by binding to the cell surface receptors.
VEGF expression is regulated by certain single nucleotide polymorphisms, which have tissue and age- specific expression patterns. Some of these polymorphisms including VEGF +405 C/G (rs2010963) which arise from the vascular expression of different VEGF protein, have been associated with CAD susceptibility.
The aim of the study was to assess the association between VEGF gene