الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
One of the most frequent diagnoses that pediatric neurologists encounter is epilepsy. Children between one and two percent of the population have epilepsy. An permanent propensity to have epileptic seizures as well as the neurobiological, cognitive, psychological, and social effects of this disease characterise the brain disorder known as epilepsy.
Roughly 25% of instances of symptomatic epilepsy are refractory. One of the strongest predictive variables in these situations is the precise location of the epileptogenic zone (EZ), which enables complete surgical excision and efficient seizure management.
A novel diagnostic technique for people with seizure disorders is advanced MRI imaging. Perfusion weighted images and arterial spin labelling sequences are advanced sequences that help detect small anomalies that standard MRI may overlook, allowing for better seizure patient management.
Protons from the incoming blood are magnetically labelled as an endogenous diffusible tracer in the technique known as arterial spine labelling (ASL), which uses MRI to measure cerebral blood flow. Regional cerebral blood flow (CBF) can be assessed using a perfusion weighted picture, which is created by the signal difference between labelled and control images. The aim of the current study was to assess the role of ASL MR perfusion in children with focal epilepsy particularly those with negative structural MRI studies.
The current study included 20 children: 15 males and 5 females. All 20 children were diagnosed with focal epilepsy or focal with secondary generalization.
MRI examinations were performed on a 3Tesla General Electric (GE) machine with conventional sequences including 3D T1, axial T2, 3D FLAIR, coronal T2 thin sections on the hippocampi, DWI and SWI. Pseudo continuous arterial spin labeling [PCASL] MR perfusion was the main sequence of study.
We analyzed the ASL perfusion abnormalities in pediatric patients presented with epileptic conditions who did not reveal structural findings in structural MRI. We found that