الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 138 |  |  |
| | | from | 138 | | |
Abstract
EDL is a NSAID with analgesic and anti-pyretic properties. It is mainly used to relief R.A. and O.A. Because of its irritation to the GI mucosa and the risk of GI bleeding, this necessitates the development of a controlled release dosage form of EDL to obtain the benefits of EDL in treatment of arthritis with minimum side effects.
BBD determined fifteen formulae containing specified amounts of the independent variables which included the speed (X1), D:P ratio (X2) and CaCl2 conc. (X3). The used polymers, sodium alginate and chitosan, aimed to control the release of EDL from the MPs.
The MPs. containing alginate only showed rough surface while chitosan-coated alginate MPs. showed smooth surface and all the MPs. were spherical in shape.
By applying the dissolution study, the drug release was decreased with increasing the amount of the polymer after two and eight hours. The increase in the speed caused an increase in the drug release after two hours, while after eight hours the increase in the speed caused an increase or a decrease in the drug release, hence the speed has a non-significant effect on the drug release after eight hours with a p-value higher than 0.1 (= 0.116). The increase in CaCl2 conc. caused an increase in the drug release after two and eight hours.
The three independent variables show a highly significant effect on the drug release after two hours (all the three variables show a p-value less than 0.05). After eight hours, the drug-polymer ratio shows a significant effect on the drug release (p-value = 0.05) while CaCl2 conc. shows a non- significant effect on the drug release with a p-value higher than 0.1 (= 0.323).
The D:P ratio emerged as the lone factor which exerts a significant effect on the drug release after eight hours.
The % EE was increased with increasing the D:P ratio and with increasing the speed while CaCl2 conc. caused a decrease in % EE. Both of the D:P ratio and the speed show a highly significant effect on the % EE with a p-value less than 0.05 while CaCl2 conc. shows only a significant effect on % EE with a p-value less than 0.1 (= 0.07).
Concerning the in-vivo evaluation of the anti-inflammatory activity of the selected EDL MPs., edema was induced in the rats paw by carrageenan injection. The effect of the five tested treatments on edema reduction was studied and the results were:
The crude drug shows maximum percent edema reduction after three hours and nearly maintained for one hour. The commercial tablets also shows maximum percent edema reduction after three hours and nearly maintained for one hour. The group which received F1 showed maximum percent edema reduction after four hours and was higher than the crude drug and the commercial tablets. Also the group which received F5 showed maximum percent edema reduction after four hours and was higher than that of the group received F1. The group which received F15 showed maximum percent edema reduction after three hours and nearly maintained for one hour and it was higher than all the other treatments used in this study.