الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a common chronic immune-mediated disease which impairs patients’ quality of life significantly. It affects mainly skin, nails and joint characterized by the presence of sharply demarcated, red plaques with adherent silvery white scales and a tendency for symmetrical distribution over the body. Psoriasis has a bimodal age of disease onset. The first peak is around 20 years and the second peak is around 60 years. People with disease onset around 20 years old have stronger genetic predisposition, they have a higher prevalence of having human leukocyte antigen region on chromosome (HLA-Cw6). The linkage to genetic factor is lower for the group with late onset disease. The etiology of psoriasis remains unclear, although there is evidence for genetic predisposition. Although there is a suggestion that psoriasis could be an autoimmune disease, no autoantigen that could be responsible has been defined yet. Psoriasis can also be provoked by external and internal triggers, including mild trauma, sunburn, infections, systemic drugs and stress. The pathogenesis of psoriasis can be explained by dysregulation of immunological cell function as well as keratinocyte proliferation /differentiation. Thymic stromal lymphopoietin (TSLP) is protein belonging to cytokine similar to IL-7 and it exerts its biological function through the TSLP-Receptor (TSLP-R). It is expressed primarily by epithelial cells at barrier surfaces such as the skin, gut and lung. It is crucial for the maturation of antigen presenting cells and hematopoietic cells.