الفهرس 
Alopecia AreataOnly 14 pages are availabe for public view
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Abstract
Alopecia areata is among the most highly prevalent human autoimmune disease, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown.
Alopecia areata affects about 5.3 million people worldwide, including males and females across all ethnic groups, with a lifetime risk of 1.7%.
Autoimmunity develops against the hair follicle, resulting in non- scaring hair loss that may begin as patches that can coalesce and progress to cover the entire scalp or eventually the entire body.
Adiponectin is a circulating hormone secreted mainly by adipose tissue. The gene of adiponectin is located on the long arm of the chromosome 3, locus 3q27.
It has been reported that adiponectin is implicated in inflammatory diseases such as metabolic syndrome (MetS), osteoarthritis, and rheumatoid arthritis (RA). It may be involved in the pathogenesis of cutaneous diseases such as psoriasis. However, its role in AA was addressed in two studies only, with a controversial result.
The aim of the work to study serum level and gene single nucleotide polymorphism of adiponectin in alopecia areata.
This study was carried out on 75 patients presenting with variable degrees AA severity. They were accounted from Outpatient Clinic of Dermatology, Faculty of Medicine, Menoufia University Hospitals during period between March 2022 and February 2023. For comparison purposes, 75 age and gender matched apparently healthy volunteers.
After obtaining a written consent, all patients were subjected to complete history taking, dermatological examination and registration of SALT score. Laboratory investigations were done to detect adiponectin serum level by ELISA and adiponectin rs2241766 SNP using PCR.
The main results of the current study revealed that:
● HDL was significantly lower and total cholesterol was significantly higher in AA patients than controls.
● Serum adiponectin level was significantly lower in AA patients than controls and negatively correlated with SALT score of AA disease.
● Regarding rs2241766, there was a significant statistical association between TG genotype and G allele and increase risk of AA by 5 and 4 times respectively
● There were significant differences between serum adiponectin level and rs2241766 genotyping, TG genotypes carrier have lower adiponectin serum level that TT genotypes carriers.