الفهرس 
Cancer therapy and induction of cardiotoxicityOnly 14 pages are availabe for public view
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Abstract
Cardiac toxicity is defined as the toxicity that affects the heart either
by a direct effect of the drug on the heart, the indirect effect due to the
enhancement of hemodynamic flow alterations or due to thrombotic
events. Cardio toxicity has an increasing relevance as a result of the global
improvement in cancer management, which leads to better survival and,
therefore, adverse effects of treatments have significant consequences on
patient outcome.
Doxorubicin (DOX) is a cytotoxic agent that comes under the class
of anthracycline antibiotics. DOX is isolated from the culture of
Streptomyces, and displays a broad spectrum activity against many
different tumor types, therefore remains one of the pillars of oncological
treatment.
The management of cardiovascular disease before and during cancer
antineoplastic treatment is essential to reduce morbidity and mortality in
cancer patients. Extensive studies have focused on identifying the methods
or drugs capable of reducing this cardiotoxicity. One of these approaches
is the use of plant products that play an important role in health care
delivery as therapeutic remedies in the world, especially in developing
countries. Medicinal plants are rich in bio-resources of drugs and these
chemical compounds play a definite physiological action in the human
body system and have always been resources of traditional and even
modern medicines, because they have effective in treating diseases