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Abstract Psychosis is a complex psychiatric disorder associated with positive symptoms including delusion, allucination and disorganized speech in addition to negative symptoms such as affective flattering, a volition and social withdrawal. Many conventional medications have been used to treat the symptoms. Understanding the risks of antipsychotic medication use in pregnancy is an important clinical concern given the evidence of their increasing rate of prescription in the general population for a range of disorders. There is a trend toward the use of newer antipsychotics, specially risperidone and olanzapine. They are both second-generation antipsychotic agents. Even though they share same in vitro properties, they differ in their chemical structure, spectrum of receptor binding affinities, neuropharmacology, pharmacokinetics, and in vivo neuroimaging profile. |