الفهرس 
Hepatic fibrosisOnly 14 pages are availabe for public view
 |  | from | 75 |  |  |
| | | from | 75 | | |
Abstract
chronic liver disease (CLD) is a major cause of morbidity and mortality worldwide with 2 million individuals dying of liver disease yearly (Asrani S.K. et al., 2019). The most common culprits are chronic hepatitis B virus (HBV), hepatitis C virus (HCV), nonalcoholic fatty liver disease (NAFLD) and alcohol-associated liver disease (ALD) (Kulik L. and El-Serag H.B., 2019).
Liver fibrosis (LF) is an ongoing chronic liver condition that develops as a result of wound healing response following long-standing liver injury; liver parenchyma undergoes architectural re-modeling including fibrillar extracellular matrix (ECM) accumulation with nodular regeneration. If left undiagnosed and untreated, it ends to loss of the normal liver function, cirrhosis, liver failure, hepatocellular carcinoma (HCC) and eventually death (Pinzani M., 2015).