الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
ErbB receptors belong to the family of receptor tyrosine kinases. The ErbB family is composed of four members: ErbB1 (also known as EGFR), ErbB2, ErbB3 and ErbB4. Different ErbB4 isoforms are present and can be classified according to their ability to be cleaved by membrane metalloproteases (JMa) or not (JMb), whether they can bind to PI3K and E3 ubiquitin ligase (cyt1) or not (cyt2), thus forming four isoforms: JMa-cyt1, JMa-cyt2, JMb-cyt1 and JMb-cyt2 that differ from each other both structurally and functionally.
Neuregulins (NRGs) are ligands for ErbB3 and ErbB4. NRGs comprise a large family of widely expressed epidermal growth factor (EGF)-like proteins. NRGs are encoded by four different genes (NRG1-4). Alternative splicing can produce up to 15 different NRG1 isoforms but all share the core EGF-like domain that is responsible for ErbB receptor binding and signalling; according to the EGF-like domain structure, two isoforms can be produced: NRG1α and NRG1β.