الفهرس 
Assessment of liver injury and genetic predisposition to drug-induced liver injury in patients receiving anti tuberculosis drugs
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Abstract
Background: Anti-tuberculosis drugs are one of the most common causes of
idiosyncratic hepatotoxicity. The antituberculosis drug-induced liver Anti TBDILI mechanism is related to cytochrome P4502E1 (CYP2E1). Genetic
polymorphism of the CYP2E1 may affect the susceptibility to Anti TB -DILI
Aim: Assessment of liver injury as well as identification of clinical risk
factors for hepatotoxicity in patients receiving anti-Tuberculosis drugs and
Assessment of frequency of CYP2E1 Polymorphisms gene and its association
with Anti TB -DILI
Materials and methods: Cohort longitudinal study was conducted on 75
patients receiving anti-tuberculosis drugs and CYP2E1 gene rs2031920
polymorphism identification was done.
Results: Males were at a higher incidence of TB (54.7%), the mean age was
35.36± 14.05. The frequency of CYP2E1 polymorphisms was CT heterozygous
(60%), CC homozygous (21%), and TT homozygous (12%). Among 75
patients ,19 patients developed (AT-DILI) (25.3%). they were categorized as
mild, moderate, and severe representing 64.7%, 11.8%, 23.5% respectively.
Among patients who developed AT-DILI, 12 patients were heterozygous CT
genotype (63.2%), 5 patients were homozygous CC genotype (26.3%) and 2
patients were homozygous TT polymorphism (12 %). 73.7% were females (P =
0.004) and 36.8% were hypertensive liver injury was significantly lower among
those taking a quadruple regimen with steroids. (P-value: 0.020)
Conclusion: There was no association between CYP2E1 polymorphisms and
anti TB DILI in this study with no statistically significant result was observed
between grading of liver injury severity and CYP2E1 polymorphisms.