الفهرس 
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Abstract
As a disfiguring skin disorder, vitiligo is characterised by the emergence of white macules on the skin, which are caused by the loss of melanocytes. Vitiligo may remain steady for extended periods of time, but it can suddenly flare up in response to stress or friction.
In most cases, vitiligo lesions return to previously afflicted areas, suggesting as vitiligo is an immunological memory skin condition. To test this hypothesis, we conducted a prospective cross-sectional research on individuals with non-segmental vitiligo to investigate and compare the existence of Metadata lymphocytes in vitiligo skin samples.
Skin samples were taken from the margins of lesions, lesions themselves, and healthy skin to conduct the immunohistochemical analysis. The infiltration of mononuclear cells was observed to be substantially greater in the bordering skin than in the non-leisonal skin in this investigation. Nonetheless, there were no discernible distinctions between leisonal skin and marginal or non-leisonal skin.
A greater proportion of CD103+ve cells may be seen in the epidermis, dermis, and combined epidermis and dermis of marginal skin compared to non-leisonal skin. However, there was no significant statistical difference here between marginal and non-lesional skin in terms of the proportion of epidermal CD103 expression. Further, there was no significant difference between non-lesional and marginal skin in terms of the proportion of CD103 expression in the dermis and the total skin layers.
There was no change in the quantity or % of CD103+ve cells in the epidermis, dermis, or total skin layers between the marginal or the leisonal skin.
According to the results of the present investigation, there is a notable difference between leisonal and non leisonal skin in terms of the quantity and percentages of CD103+ve cells within the epidermis and indeed the skin graft strata (epidermis and dermis). Yet, neither the number nor distribution of CD103+ve cells in the dermis differed significantly between leisonal and non-leisonal skin.
According to the results of this investigation, neither the absolute number nor the proportion of CD103+ve cells increased with age. Also, the quantity and % of CD103+ve cells did not significantly correlate with the period of vitiligo illness, with the exception of the dermis and general skin strata of leisonal skin, where a strong negative connection was identified.
Furthermore, the present investigation found no statistically significant shift in the number of CD103+ve s either in the leisonal or without leisonal skin between active and stable patients (epidermis, dermis or total).
There was a considerable increase in the number of CD103+ve s in the dermal and overall skin layers of the leisonal membrane in active cases compared to stable patients.
Epidermal, dermal, and total CD103+ve cells in non-leisonal skin and epidermal CD103+ve cells in leisonal skin did not vary significantly between both active and stable instances.
The quantity and percentages of CD103+ve cells were significantly lower in the epidermal layer than in the dermal layer or the total skin layer in marginal, leisonal, and non leisonal tissue.
The quantity and proportion of CD103+ve cells in the epidermal layer of both leisonal & non leisonal skin was significantly lower in active cases compared to the dermal & total skin layers. However, in stable instances, CD103+ve cells decreased significantly in the epidermal layer relative to the total skin layers, and this was true only for non leisonal skin. There was no significant difference between the epidermal and dermal layers of leisonal skin in terms of the quantity or percentage of CD103+ve s in stable instances.