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Abstract
The aims of this work are production and risk evaluation of some functional ingredients from the dominants microalgae in Egyptian aquatic. These were achieved throughout the study of ingredients activity against pathogens and cancer cells. In addition to the assessment of the fuctional ingredients (amino acids, fatty acids, minerals and pigments) in Spirulina platensis as a model for the other species under study. Ninety eight species of phytoplankton from 4 different sites were identified to specify the dominant species. Six species were isolated and purified. Four of them (Oscillatoria brevis, O. princeps, Microcystis aeruginosa and Spirulina platensis) belonged to Cyanophyta and the other two (Chlorella vulgaris and Scenedesmus obliquus) belonged to Chlorophyta. Because of the ability to produce Microcystin, O. brevis and M. aeruginosa were excluded from the study. Diethyl ether extract (DEE) of C. vulgaris gave the best inhibition being between 11.5 and 23.2 mm inhibition zone against all tested bacteria and fungi. Regarding to anticancer activity of DEE, the highest effect at LC50 was observed against both of HepG2 and MCF7 cell lines. Two compounds were identified as Hydroxyphenophytin B and Hexadecanoic acid Methyl ester. DEE of S. obliquus had the highest antimicrobial activity recording between 8.7 and 19.5 mm inhibition zones against bacteria and fungi.