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Abstract
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of anti-platelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Aim:The current case-control study aimed at detecting the frequency of IL-23R gene polymorphism in egyptian children with ITP and its possible role as a genetic marker for ITP risk. Materials and Methods: IL-23R gene polymorphism was studied in 50 ITP patients and 100 healthy age and sex matched controls by PCR amplification of the target gene followed by allele specific restriction enzyme digestion (RFLP technique). Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.