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Abstract
Diabetes mellitus is one of the main threats to human health in the twenty-first century. Visfatin and resistin are adipokines which have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) complications. Several genetic studies have shown inconsistent results regarding association of visfatin and resistin gene polymorphisms with T2DM and CVD complications. Subjects and methods: Here we investigate whether visfatin -948G/T and resistin -420C/G polymorphisms are associated with T2DM, its CVD complications and serum adipokine levels in 90 Egyptian diabetic patients (44 without CVD and 46 with CVD) along with 60 healthy control subjects. Polymorphisms of visfatin -948G/T and resistin-420C/G genes were detected by Real time-PCR and PCR-RFLP, respectively. Serum visfatin and resistin were measured by ELISA. Results: Higher frequencies of visfatin -948G/T and resistin -420C/G were observed among T2DM patients compared to controls