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Abstract
Vasopressin plays a crucial role in the endocrine stress response to a variety of diseases such as hypoxic ischemic encephalopathy and early onset sepsis. Vasopressin is derived from a larger precursor peptide which contains also C-terminal pro-vasopressin, called copeptin Upon release of vasopressin, equal amounts of copeptin are secreted. Aim of work: Detection of copeptin cord blood concentrations in perinatal asphyxia and neonatal sepsis. Methods: The study included 105 neonates (near term and full term ). Divided into three group,perinatal asphyxia ,early onset sepsis and control groups. Every group included 35 neonates .Copeptin cord blood concentration was determined by ELISA