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Abstract
Chemically modified carbon paste sensors (CMCPSs) for determination of clomipramine hydrochloride (CLP.HCl) were prepared based on the use of ion-exchange compounds of clomipramine-tetraphenylborate(CLP-TPB) and clomipramine-silicotungestate(CLP-ST) as the electroactive materials.The potential response measurements showed that the best performance was exhibited by the sensors with composition 2% CLP-TPB, 49% o-NPPE and 49% graphite powder and 7% CLP-ST, 46.5% o-NPOE and 46.5 graphite powder.The sensors were found to be sensitive, precise and functional in the concentration ranges of 3.74{u00D7}10-6-1.00{u00D7}10-2 and 3.98{u00D7}10-6-1.00{u00D7}102mol L-1at 25±1 {u00BA}C over the pH range 2.10-7.57 and 2.00-7.34 with slopes of 60.53±0.14 and 59.22±0.12 mV decade-1for CLP-TPB and CLP-ST sensors, respectively. The detection limitsand limits of quantification were calculated to be 2.70{u00D7}10-6 and 8.99{u00D7}10-6mol L-1for CLP-TPB and 2.26{u00D7}10-6and 7.52{u00D7}10-6mol L-1for CLP-ST sensors. The response time is about 10 s for both sensors