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Abstract
Introduction and aim of work: Assessment of the individualized SUVs, PET-derived total metabolic tumor volume (TMTV) and the product of both parameters, termed total lesion glycolysis (TLG) in both initial and interim PET if it carries a better PPV in early assessment of response to therapy in pediatric Hodgkin{u2019}s lymphoma (PHL) patients. Results: Out of the 60 interim-PET scans, 50 scans were considered as PET2-ve (83.3%), 5 scans as PET2+ve (8.3%) and 5 scans as PET2-MRU (8.3%). The risk of the disease and the visual scoring assessment were significantly correlated with patient’s outcome (whether Negative or Residual/Relapse) (p <0.0001). Different results were obtained; the most important were TLGmax2.5 (cut-off 2.5), TLGmean2.5 (cut-off 2) and TMTV2.5 (cut-off 0.75 ccm) in interim PET showed the highest sensitivity, specificity, PPV and NPV (58.5%, 97.9%, 87.5% and 90.3% respectively for the 3 parameters).