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Abstract
The aim of this study was to monitor the effect of acetylcholine (Ach) Iontophoresis on microcirculation changes in type 2 diabetes mellitus. Methods: forty patients with type 2 diabetes mellitus (15men and 25women) selected from Kasr al Aini hospital (out patients diabetes clinic). Aged 40-60 years included in the present study. Patients divided into two groups equal in number: Study group (A) 20 type 2 diabetes mellitus patients without neuropathy, and study group (B) 20 type 2 diabetes mellitus patients with neuropathy. Both groups received a program of acetylcholine iontophoresis (15 min. current intensity 3-5 mA, 3times/week). The changes in microcirculation measured by laser Doppler fluximetry (LDF) at the beginning of the study and after two weeks. Results: Showed statistical significant improvement (P<0.05) in the base line of microcirculation at (30oc temperature) (180.65%), at 35 temperature (219.45%) and with acetylcholine iontophoresis (269.60%) in group (A). And statistical significant improvement (P<0.05) in the base line of microcirculation at (30 temperature) (131.50%), at 35 temperature (149.40%) and with acetylcholine iontophoresis (236.95%) in group (B). But this significant improvement was more in group (A) than in group (B), may be due to the effect of diabetic neuropathy on microcirculation in group (B). Conclusion: The results proved that a program of acetylcholine iontophoresis showed significant improvement in microcirculation in type 2 diabetes mellitus patients