الفهرس 
Detection of serum and salivary IL-8 in patients with Premalignant lesions and Oral Squamous Cell Carcinoma patients
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Abstract
Head and neck cancers constitute the sixth most common malignant tumors worldwide, causing almost 350,000 cancer deaths per year. Oral cancer is the most frequent cancer of the head and neck district, with squamous cell carcinoma (SCC) being the commonest single entity and highly aggressive malignancies, accounting for about 90% of all malignancies of the oral cavity. Oral cancer develops in stages, transitioning from a normal oral epithelium, to a pre-malignant, dysplastic oral lesion, to a malignant lesion, most commonly in the form of OSCC. Chemokines play an important role in leukocyte homeostasis, in inflammation, and also in angiogenesis and tumor metastasis. Tumor cells secrete and respond to chemokines facilitating tumor growth and metastasis by increasing endothelial cell recruitment and maneuvering of the tumoral leukocyte profile. Thus chemokines are vital for tumor progression