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Abstract This case control study was done on 80 child, 40 of them diagnosed with autistic spectrum disorders by DSM-V-TR criteria with no another medical disease and another 40 apparently healthy matched age children, from their brothers as a control group. All children attended to psychiatric and neurology clinic, pediatric department, Menoufia University Hospital in Shebin El Kom city, Menoufia governorate, Egypt during the period study from April 2019 to January 2020. All study patients were divided in two groups: Cases group: included 40 children (31 boys and 9 girls), with ages ranging from 2 to 11 years with mean of 6.5±2.5 years and diagnosed with ASDs on the basis of the DSM- V-TR criteria. Control group: enrolled 40 apparently healthy children (15 boys and 25 girls), with ages ranging from 2 to 11 years, from their brothers. All controls were also clinically examined by the pediatricians to exclude the possibility to have any subclinical autistic features. All cases were subjected to the following: Detailed history taking with special emphasis on; onset, course and duration of the disease and age, sex of the patient consanguinity. Antenatal or maternal history: age at patient’s birth, history of chronic illness as hypertension, Diabetes mellitus (DM) obesity, depression, epilepsy and PCO. During pregnancy: Medications (e.g.: antiepileptic drugs) fever, bleeding, smoking. Natal and postnatal history including, complication during labour or delivery, history of prematurity, gestational age at birth, birth weight, perinatal problems and postnatal course especially occurrence of neonatal hypoxia and jaundice. Developmental history (both mental and motor): age of sitting up without support, walking unassisted, first spoken word and history of vaccination. Past history including major childhood illnesses, any previous therapies used to treat the child’s condition .Family history for any similar conditions, any genetic diseases and other psychological or mental disorders in the family. History of exposure to heavy metals, Dental fillings, silver/mercury fillings in pregnancy, near factory, industry, highway residence anti-D inject, Taking antibiotics during pregnancy. scaling the socioeconomic level of their families. previously prepared questionnaire for assessment of risk factors of autism spectrum disorders. Assessment of the quality of life: Overall Quality of Life and General Health physical health domai, Psychological domain, Social relationships, Spiritual life and Environmental domain. Results showed that there were highly significant differences between cases and control groups regarding: Gender, history of hypertension, and diabetes mellitus during pregnancy. Irregular folic–iron intake, fever, bleeding, Induced labor and precipitous labor Dental fillings, Silver/mercury fillings in pregnancy and taking antibiotics during pregnancy, >4.5 kg, Neonatal unit and Jaundice. |